5-Amino-1MQ (5-amino-1-methylquinolinium) is a synthetic small-molecule quaternary quinolinium cation, supplied as its iodide salt. It belongs to the N-methylated quinolinium series described in structure–activity studies of nicotinamide N-methyltransferase (NNMT) inhibitors and is structurally related to 1-methylquinolinium, the product of NNMT-catalysed methylation of quinoline. It is not a peptide.

NNMT transfers a methyl group from S-adenosyl-L-methionine (SAM) to nicotinamide and related pyridines, forming 1-methylnicotinamide (1-MNA) and S-adenosyl-L-homocysteine. Methylquinolinium analogues have been reported to inhibit NNMT in enzyme assays with low-micromolar IC50 values (approximately 1 µM), and docking studies place them in the nicotinamide substrate-binding site. Amino-substituted methylquinoliniums were also reported to be membrane-permeable, selective over related SAM-dependent methyltransferases and NAD+ salvage enzymes, and to lower intracellular 1-MNA while raising NAD+ and SAM in cultured adipocytes.

5-Amino-1MQ is cited in enzymology and cell-metabolism research, including NNMT kinetics and structure–activity studies, NAD+ salvage-pathway and methyl-donor (SAM) flux experiments, and adipocyte cell models. As an iodide salt, the solid is best kept dry and protected from light.

Research use only. This material is sold for in-vitro laboratory research and development purposes exclusively. It is not a drug, food, or dietary supplement, has not been evaluated by the FDA, and must not be used in humans or animals.