Kisspeptin-10 (KP-10) is a linear decapeptide, Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH₂, corresponding to residues 45–54 of human kisspeptin-54 (metastin), the principal processed product of the KISS1 gene. It is the shortest endogenous kisspeptin fragment and carries the C-terminal Arg-Phe-amide motif that places the kisspeptins within the RF-amide peptide family.

Kisspeptin-10 is reported to bind and activate KISS1R (GPR54), a class A G-protein-coupled receptor, with potency comparable to the longer kisspeptin isoforms. KISS1R couples predominantly to Gq/11, leading to phospholipase C activation, inositol phosphate accumulation, intracellular calcium release and ERK1/2 phosphorylation. Structure–activity studies identify the amidated C-terminal residues as essential for receptor activation.

Research citing kisspeptin-10 includes KISS1R pharmacology in recombinant cell lines, hypothalamic–pituitary signalling and GnRH-neuron electrophysiology in tissue preparations, and structure–activity and stability studies used to design truncated or modified KISS1R agonists. The native peptide is susceptible to proteolytic cleavage, which is a consideration in assay design.

Research use only. This material is sold for in-vitro laboratory research and development purposes exclusively. It is not a drug, food, or dietary supplement, has not been evaluated by the FDA, and must not be used in humans or animals.