MOTS-c (mitochondrial open reading frame of the 12S rRNA type-c) is a 16-residue peptide, MRWQEMGYIFYPRKLR, encoded within the mitochondrial 12S rRNA gene. It belongs to the mitochondrial-derived peptides, a small group of signalling peptides translated from short open reading frames in the mitochondrial genome.

In cultured cells under metabolic stress, MOTS-c has been reported to move from the cytoplasm into the nucleus. There it regulates nuclear gene expression, including genes with antioxidant response elements, in cooperation with the transcription factor NRF2. Reviews also describe its association with AMPK signalling and with mitochondrial function in models of cellular senescence.

The peptide is cited in research on mitochondrial–nuclear communication, mitochondrial-derived peptides and cellular stress-response signalling. Its two methionines and tryptophan are prone to oxidation and light damage, so material should be kept dark and sealed.

Research use only. This material is sold for in-vitro laboratory research and development purposes exclusively. It is not a drug, food, or dietary supplement, has not been evaluated by the FDA, and must not be used in humans or animals.